Developing juvenile localized scleroderma (jLS) consensus treatment regimens for comparative effectiveness studies
نویسندگان
چکیده
Purpose LS can cause significant morbidity in the growing child, including joint contractures and facial and extremity hemiatrophy. Optimal therapy is not known, and few randomized clinical trials have been carried out. A prior survey of Childhood Arthritis and Rheumatology Research Alliance (CARRA) members identified methotrexate (MTX) and corticosteroids (CS) as the most commonly used medications to treat serious jLS. However, there was no consensus on dose, route of administration, or duration of treatment for these medications. Objective: To develop standardized consensus treatment regimens and disease assessments tools for jLS.
منابع مشابه
Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil.
OBJECTIVE To evaluate the efficacy of mycophenolate mofetil (MMF) in the treatment of severe refractory juvenile localized scleroderma (JLS). METHODS A retrospective chart review was performed in patients with JLS who had been treated with MMF after the failure of a combination of MTX and corticosteroids for at least 4 months, or whose JLS had concomitant severe extracutaneous manifestations....
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Introduction JLS is a chronic, autoimmune disease, characterized by skin and subcutaneous tissues fibrosis, which can extend to underlying tissues up to muscle and bone. JLS can cause a poor quality of life and psychosocial and behavioural problems in affected children particularly when severe deformities such as face asymmetry, joint contractures, and growth disturbances of limbs develop. To d...
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OBJECTIVES Juvenile localized scleroderma (JLS) is a rare condition that is often difficult to assess and for which a variety of monitoring tools have been described. We aimed to describe how monitoring tools are used and perceived by clinicians in the UK, to ascertain treatments used for JLS and to provide a description of transition arrangements to adult care. METHODS An e-survey of UK paed...
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Received: Jan 09, 2013 Accepted: Jan 16, 2013 Ann Paediatr Rheum 2013; 2:43-49 DOI: 10.5455/apr.011620131348 Introduction Juvenile localized scleroderma ( JLS) is a childhood condition characterized by thickening of the skin. A variety of clinical subtypes have been described, differentiated by the size, shape, and location of skin involvement as well as the presence or absence of extra-cutaneo...
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